Spermine → (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal

HRID 884323Notes

Reaction equation

HRID 884323 reaction equation
NCCCNCCCCNCCCN.[C@@H:15]1([O:46]P(O)(O)=O)[C@@H:20]([O:21]P(O)(O)=O)[C@H:19]([O:26]P(O)(O)=O)[C@@H:18]([O:31]P(O)(O)=O)[C@@H:17]([O:36]P(O)(O)=O)[C@H:16]1[O:41]P(O)(O)=O>>[O:21]=[CH:20][C@@H:19]([C@H:18]([C@@H:17]([C@@H:16]([CH2:15][OH:46])[OH:41])[OH:36])[OH:31])[OH:26]

Participants

3

Reactant 2

HCID 1103SpermineHCID 178527091HCID 178527091, compound

Product 1

HCID 107526(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal

Procedure

A composition contemplated by the instant invention was prepared by dissolving human insulin with spermine and phytic acid in double distilled water (“DDW”) containing NaOH. The solution was then lyophilized and suspended with sodium dodecanoate (SD), octanol and geraniol in a mixture of mineral oil, medium chain triglyceride (MCT) oil and castor oil. Components and concentrations are detailed in Table 1.

Workup

  1. customwas prepared
  2. distillationin double distilled water (“DDW”)
  3. additioncontaining NaOH
  4. additionsuspended with sodium dodecanoate (SD), octanol and geraniol in a mixture of mineral oil, medium chain triglyceride (MCT) oil and castor oil
  5. concentrationComponents and concentrations

Sources & evidence

ORD record
ord-d34855ce44584ab087d42f08dc818a1c
Source dataset
uspto-grants-2012_08
Patent number
US08241670B2

Reaction notes

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