Trichloroacetyl chloride → 2,2,2-trichloro-N-(3-methylcinnolin-5-yl)acetamide

HRID 887176

Reaction equation

HRID 887176 reaction equation
[CH3:1][C:2]1[N:3]=[N:4][C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([NH2:12])[C:10]=2[CH:11]=1.[Cl:13][C:14]([Cl:19])([Cl:18])[C:15](Cl)=[O:16]>C(N(CC)CC)C>[Cl:13][C:14]([Cl:19])([Cl:18])[C:15]([NH:12][C:9]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:10]=1[CH:11]=[C:2]([CH3:1])[N:3]=[N:4]2)=[O:16]

Participants

4

Reactant 2

HCID 6420Trichloroacetyl chlorideHCID 53106453-Methylcinnolin-5-amine

Product 1

HCID 220326582,2,2-trichloro-N-(3-methylcinnolin-5-yl)acetamide

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The title compound was prepared using 3-methylcinnolin-5-amine (commercially available, Maybridge), triethylamine, trichloroacetyl chloride and the procedure described in Example 1A.

Sources & evidence

ORD record
ord-cfa6364a967549408c521f1a36fd95c2
Source dataset
uspto-grants-2012_08
Patent number
US08247413B2

Linked notes

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