Iodine → 2-cyclopropyl-5-iodo-1H-imidazole

HRID 8890

Reaction equation

C1(C2NC=CN=2)CC1.II.[OH-].[Na+].[I:13][C:14]1[N:15]=[C:16]([CH:20]2[CH2:22][CH2:21]2)[NH:17][C:18]=1I.S([O-])([O-])=O.[Na+].[Na+]>>[CH:20]1([C:16]2[NH:15][C:14]([I:13])=[CH:18][N:17]=2)[CH2:22][CH2:21]1

Participants

Reactant 5

HCID 807Iodine

HCID 14798Sodium Hydroxide

HCID 24437Sodium Sulfite

HCID 179423832-cyclopropyl-1H-imidazole

HCID 219853952-Cyclopropyl-4,5-diiodo-1h-imidazole

Product 1

HCID 219853922-cyclopropyl-5-iodo-1H-imidazole

Procedure

The title compound was prepared in accordance with the literature reference of Cliff & Pyne, Synthesis-Stuttgart (7), 681–682(1994) by reacting 2-cyclopropyl-1H-imidazole with iodine in the presence of NaOH. The obtained 4,5-diiodo-2-cyclopropyl-1H-imidazole was then reacted with sodium sulfite to obtain the title compound.

Sources & evidence

ORD record: ord-4a51539e54e6499c8098a02ac20b71d4
Source dataset: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07091222B2

Linked notes

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