Methanesulfinyl chloride → HCID 58545437, compound

HRID 889662

Reaction equation

HRID 889662 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][NH2:9])=[CH:4][CH:3]=1.[CH3:10][S:11](Cl)=[O:12]>O1CCCC1>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][NH:9][S:11]([CH3:10])=[O:12])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 548463Methanesulfinyl chlorideHCID 70209275-(Aminomethyl)-2-chloropyridine

Product 1

HCID 58545437HCID 58545437, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Methanesulfinyl chloride was obtained as described in the literature. A solution of C-(6-chloro-pyridin-3-yl)-methylamine (2.1) (25 g, 178 mmol) in tetrahydrofuran (200 ml) was cooled to 0° C. and methanesulfinyl chloride (7 g, 71 mmol) was added dropwise. The solution was allowed to warm to room temperature and stirred for 16 hours. The precipitate was removed by filtration, the filtrate was diluted with EtOAc and washed with H2O. The organic phase was dried over Na2SO4 and evaporated under reduced pressure.

Workup

  1. customThe precipitate was removed by filtration
  2. additionthe filtrate was diluted with EtOAc
  3. washwashed with H2O
  4. dry with materialThe organic phase was dried over Na2SO4
  5. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-3be19a7127c34e83a55bdf5cf018e576
Source dataset
uspto-grants-2012_08
Patent number
US08252939B2

Linked notes

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