Tetrahydrofuran → 2-{[4-(Dimethylaminomethyl)piperidin-1-yl]carbonylamino}-4-(4-{3-[2-(4-fluorophenyl)acetyl]ureido}phenoxy)pyridine

Reaction equation

[F:28][c:29]1[cH:30][cH:31][c:32]([CH2:35][C:36](=[O:37])[N:38]=[C:39]=[O:40])[cH:33][cH:34]1.[NH2:1][c:2]1[cH:3][cH:4][c:5]([O:6][c:7]2[cH:8][c:9]([NH:13][C:14](=[O:15])[N:16]3[CH2:17][CH2:18][CH:19]([CH2:22][N:23]([CH3:24])[CH3:25])[CH2:20][CH2:21]3)[n:10][cH:11][cH:12]2)[cH:26][cH:27]1.[O:41]1[CH2:42][CH2:43][CH2:44][CH2:45]1>>[NH:1]([c:2]1[cH:3][cH:4][c:5]([O:6][c:7]2[cH:8][c:9]([NH:13][C:14](=[O:15])[N:16]3[CH2:17][CH2:18][CH:19]([CH2:22][N:23]([CH3:24])[CH3:25])[CH2:20][CH2:21]3)[n:10][cH:11][cH:12]2)[cH:26][cH:27]1)[C:39]([NH:38][C:36]([CH2:35][c:32]1[cH:31][cH:30][c:29]([F:28])[cH:34][cH:33]1)=[O:37])=[O:40]