Hydrochloric Acid → 2-Ethylcyclohexylisocyanate

HRID 890366Notes

Reaction equation

HRID 890366 reaction equation
[CH2:1]([CH:3]1[CH2:8][CH2:7][CH2:6][CH2:5][CH:4]1[NH2:9])[CH3:2].Cl.[C:11](Cl)(Cl)=[O:12]>CO>[CH2:1]([CH:3]1[CH2:8][CH2:7][CH2:6][CH2:5][CH:4]1[N:9]=[C:11]=[O:12])[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6371PhosgeneHCID 5448542-Ethylcyclohexan-1-amine

Product 1

HCID 222509222-Ethylcyclohexylisocyanate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
110 °C

Procedure

To a solution of 2-ethylcyclohexylamine (0.61 mmol) in methanol was added HCl (4.0 M in dioxane, 0.152 mL), and concentrated to give a residue. Phosgene solution (20% in toluene, 6.0 mL) was added, and the reaction was heated at 110° C. overnight. Toluene and excess of phosgene were removed in vacuo to give a residue.

Workup

  1. concentrationconcentrated
  2. customto give a residue
  3. customToluene and excess of phosgene were removed in vacuo
  4. customto give a residue

Sources & evidence

ORD record
ord-0f7d26ca9bd248889f2a788c0d2faa80
Source dataset
uspto-grants-2006_02
Patent number
US06995269B2

Reaction notes

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