Acetic Acid → N-Acetyl-L-alanine

HRID 890688

Reaction equation

HRID 890688 reaction equation
[NH2:1][CH:2]([C:4]([OH:6])=[O:5])[CH3:3].[C:7](O)(=[O:9])[CH3:8].C(OC(=O)C)(=O)C>C(OCC)(=O)C>[C:7]([NH:1][C@H:2]([C:4]([OH:6])=[O:5])[CH3:3])(=[O:9])[CH3:8]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 602DL-alanineHCID 7918Acetic Anhydride

Product 1

HCID 88064N-Acetyl-L-alanine

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
100 °C

Procedure

134 g (1.50 mol) of DL-alanine are introduced into acetic acid and treated dropwise with 230 g (2.25 mol) of acetic anhydride. The mixture is additionally stirred at 100° C. for 2 h to complete the reaction and the solvent is then stripped off in vacuo. The solid obtained is suspended in ethyl acetate and filtered off with suction. For purification, the solid is washed several times with diethyl ether.

Workup

  1. customthe reaction
  2. customThe solid obtained
  3. filtrationfiltered off with suction
  4. customFor purification
  5. washthe solid is washed several times with diethyl ether

Sources & evidence

ORD record
ord-7a7506be6c624ae69389ab1b1fb4279d
Source dataset
uspto-grants-2006_02
Patent number
US06998402B2

Linked notes

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