HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → N-{1-[3-(4-methoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 2-(4-Methoxyphenyl)ethanimidamide hydrochloride | HCID 12203394 | — |
| Reactant | Ethyl 3-acetamido-2-oxobutanoate | HCID 22245807 | — |
| Product | N-{1-[3-(4-methoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}acetamide | HCID 135697913 | — |
Reaction Steps
Analogously to Example 7A, 5.1 g (25.4 mmol) of 2-(4-methoxyphenyl)ethanamidine hydrochloride (Example 4A) are reacted with 1.53 g (30.5 mmol) of hydrazine hydrate and 7.14 g (38.1 mol) of ethyl 3-(acetylamino)-2-oxobutanoate (Example 6A) to give N-{1-[3-(4-methoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}acetamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06998402B2 |
| Source dataset | uspto-grants-2006_02 |
| ORD ID | ord-77ceaf58325a4be4b408ff2d4a5ca463 |
| Source note | uspto-grants-2006_02 |