Ethyl isocyanate → 1-(3-Fluorobenzoyl)-4-ethyl semicarbazide

HRID 892702

Reaction equation

HRID 892702 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([NH:7][NH2:8])=[O:6].[CH2:12]([N:14]=[C:15]=[O:16])[CH3:13]>O1CCCC1>[F:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([NH:7][NH:8][C:15]([NH:14][CH2:12][CH3:13])=[O:16])=[O:6]

Participants

4

Reactant 2

HCID 8022Ethyl isocyanateHCID 3516403-Fluorobenzohydrazide

Product 1

HCID 190109271-(3-Fluorobenzoyl)-4-ethyl semicarbazide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 3-fluorobenzhydrazide (5.0 g, 0.033 mol) in tetrahydrofuran (100 mL) was added ethyl isocyanate (2.6 g, 0.036 mol) at room temperature. After stirring for 24 hr, the resultant precipitate was collected by suction-filtration to give 1-(3-fluorobenzoyl)-4-ethyl semicarbazide in quantitative yield.

Workup

  1. filtrationthe resultant precipitate was collected by suction-filtration

Sources & evidence

ORD record
ord-7a267d82ff984923867c981c93aa46c0
Source dataset
uspto-grants-1992_06
Patent number
US05120347

Linked notes

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