Ethyl isocyanate → 4-Ethyl-2-propyl semicarbazide

HRID 892704

Reaction equation

HRID 892704 reaction equation
C(O)(=O)C(O)=O.[CH2:7]([NH:10][NH2:11])[CH2:8][CH3:9].C(=O)([O-])[O-].[Na+].[Na+].[CH2:18]([N:20]=[C:21]=[O:22])[CH3:19]>O.O1CCCC1>[CH2:18]([NH:20][C:21](=[O:22])[N:10]([CH2:7][CH2:8][CH3:9])[NH2:11])[CH3:19]

Participants

6

Reactant 3

HCID 8022Ethyl isocyanateHCID 10340Sodium CarbonateHCID 96079Hydrazine, propyl-, ethanedioate (1:1)

Product 1

HCID 190109294-Ethyl-2-propyl semicarbazide

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a stirred slurry of 3.35 g (20 mmol) of n-propylhydrazine oxalate and 2.24 g (20 mmol) of sodium carbonate in 50 mL of water and 10 mL of tetrahydrofuran (THF) was added 1.7 mL (21.5 mmol) of ethyl isocyanate. The mixture was stirred at room temperature for 16 h and evaporated in vacuo to leave crude 4-ethyl-2-propyl semicarbazide as a white solid.

Workup

  1. customevaporated in vacuo

Sources & evidence

ORD record
ord-61f34be8796249b9ad6e01ef2580be67
Source dataset
uspto-grants-1992_06
Patent number
US05120347

Linked notes

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