Trifluoroacetic acid → 3-Benzyl-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one Trifluoroacetate
Reaction equation
[CH2:1]([N:8]1[C:12](=[O:13])[C:11]2([CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]2)[N:10]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:32][C:33]([F:38])([F:37])[C:34]([OH:36])=[O:35]>>[F:32][C:33]([F:38])([F:37])[C:34]([OH:36])=[O:35].[CH2:1]([N:8]1[C:12](=[O:13])[C:11]2([CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[N:10]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1Participants
3
Procedure
3-Benzyl-8-(tert-butoxycarbonyl)-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one (1.671 g) was added with trifluoroacetic acid (32 ml) with ice cooling and stirred at the same temperature for 1 hour. The solvent was evaporated under reduced pressure and then the residue was added with diisopropyl ether (50 ml) to precipitate the product. The precipitates was collected by filtration and dried to obtain 1.561 g of the title compound. Yield: 91%.