Ethyl Acetoacetate → Ethyl 2-ethyl-3-hydroxybutanoate

HRID 898502

Reaction equation

[CH2:1]([CH:3]([C:9](=[O:11])[CH3:10])[C:4]([O:6][CH2:7][CH3:8])=[O:5])[CH3:2].C(OCC)(=O)CC(C)=O>>[CH2:1]([CH:3]([CH:9]([OH:11])[CH3:10])[C:4]([O:6][CH2:7][CH3:8])=[O:5])[CH3:2]

Participants

Reactant 2

HCID 8868Ethyl Acetoacetate

HCID 79065Butanoic acid, 2-ethyl-3-oxo-, ethyl ester

Product 1

HCID 231986Ethyl 2-ethyl-3-hydroxybutanoateYield 60%

Procedure

Ethyl 2-ethyl-3-hydroxybutyrate was prepared following the procedure as described in step 1) of Preparation Example 2, except for that ethyl 2-ethyl-3-oxo-butyrate was used to replace for ethyl acetoacetate. Yield 60%.

Workup

customof Preparation Example 2

Sources & evidence

ORD record: ord-9c943762f252480d883428cdefae8d39
Source dataset: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07351778B2

Linked notes

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