Hydrazine hydrate (1:1) → (6-Methyl-5-propyl-pyrimidin-4-yl)-hydrazine
Reaction equation
[CH2:1]([C:4]1[C:5](Cl)=[N:6][CH:7]=[N:8][C:9]=1[CH3:10])[CH2:2][CH3:3].O.[NH2:13][NH2:14]>C(O)C>[CH3:10][C:9]1[N:8]=[CH:7][N:6]=[C:5]([NH:13][NH2:14])[C:4]=1[CH2:1][CH2:2][CH3:3]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 80 °C
Procedure
A mixture of 5-propyl-4-chloro-6-methyl-pyrimidine (10 mmol) and hydrazine monohydrate (30 mmol) in ethanol (20 mL) is heated at 80° C. overnight. Solvent is removed in vacuo and the residue solid is in the next step without further purification.
Workup
- customSolvent is removed in vacuo
- customthe residue solid is in the next step without further purification
Sources & evidence
- ORD record
- ord-3775f99fbe434de3b2e2bdabf0ff50f2
- Source dataset
- uspto-grants-2008_04
- Patent number
- US07351826B2
Reaction notes
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