Acetate → 3-bromo-5-chloro-N-(6-methoxypyridin-3-yl)pyrazin-2-amine

Reaction equation

[Br:1][c:2]1[c:3]([NH2:9])[n:4][cH:5][c:6]([Cl:8])[n:7]1.[C:33]([O-:34])(=[O:35])[CH3:36].[C:38]([O-:39])(=[O:40])[CH3:41].[CH3:10][O:11][c:12]1[cH:13][cH:14][c:15]([B:18]([OH:19])[OH:20])[cH:16][n:17]1.[CH:21]([N:22]([CH2:23][CH3:24])[CH:25]([CH3:26])[CH3:27])([CH3:28])[CH3:29].[Cl:30][CH2:31][Cl:32].[Cu+2:37]>>[Br:1][c:2]1[c:3]([NH:9][c:15]2[cH:14][cH:13][c:12]([O:11][CH3:10])[n:17][cH:16]2)[n:4][cH:5][c:6]([Cl:8])[n:7]1

Participants

Reactant 6

HCID 175Acetate2×

HCID 6344Dichloromethane

HCID 27099Cupric cation

HCID 81531Diisopropylethylamine

HCID 2734368(6-Methoxypyridin-3-yl)boronic acid

HCID 104886093-Bromo-5-chloropyrazin-2-amine

Product 1

HCID 866470673-bromo-5-chloro-N-(6-methoxypyridin-3-yl)pyrazin-2-amine

Sources & evidence

ORD record: ord-0e92293e932f48cda83abdfcfd6bab43
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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