Dichloromethane → 2-Methyl-2-(piperazin-1-yl)propan-1-ol

Reaction equation

[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][N:11]([C:14]([CH2:15][OH:16])([CH3:17])[CH3:18])[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:26][CH2:27][Cl:28].[F:19][C:20]([F:21])([F:22])[C:23]([OH:24])=[O:25]>>[NH:8]1[CH2:9][CH2:10][N:11]([C:14]([CH2:15][OH:16])([CH3:17])[CH3:18])[CH2:12][CH2:13]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 57420345Tert-butyl 4-(1-hydroxy-2-methylpropan-2-yl)piperazine-1-carboxylate

Product 1

HCID 120525542-Methyl-2-(piperazin-1-yl)propan-1-ol

Sources & evidence

ORD record: ord-6da8ab1e26694c5aae5494bf84c98f01
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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