Sodium Carbonate → Ethyl 4-nitro-L-phenylalanine
Reaction equation
Cl.[CH2:2]([O:4][C:5](=[O:18])[C@H:6]([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=1)[NH2:7])[CH3:3].C([O-])([O-])=O.[Na+].[Na+]>C(OCC)(=O)C>[CH2:2]([O:4][C:5](=[O:18])[C@H:6]([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=1)[NH2:7])[CH3:3]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
4-nitrophenylalanine ethyl ester hydrochloride (2 g, 1.0 eq, 7.28 mmol) obtained in step (i) was dissolved in ethyl acetate (150 mL). To that Na2CO3 (386 mg, 0.5 eq, 3.64 mmol) was added and was stirred for 15 min. The reaction mixture was washed with aq. NaHCO3. The organic layer was dried (Na2SO4), and condensed to obtain 4-nitrophenylalanine ethyl ester as thick oil (1.55 g, 89%).