2,4-Dichloro-6'-fluoro-2'-methoxy-biphenyl → 2',4'-Dichloro-6-fluoro-biphenyl-2-ol

HRID 902380

Reaction equation

HRID 902380 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:14]([O:15]C)=[CH:13][CH:12]=[CH:11][C:10]=1[F:17]>Br>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:14]([OH:15])=[CH:13][CH:12]=[CH:11][C:10]=1[F:17]

Participants

3

Reactant 1

HCID 691174512,4-Dichloro-6'-fluoro-2'-methoxy-biphenyl

Product 1

HCID 691181582',4'-Dichloro-6-fluoro-biphenyl-2-olYield 89%

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

Treatment of 2,4-dichloro-2′-fluoro-6′-methoxybiphenyl (5.0 g, 18.4 mmol) with hydrogen bromide (33% in acetic acid, 100 mL) according to the procedure described for Example 69, Step 2 provided 4.2 g (89%) of 2′,4′-dichloro-6-fluorobiphenyl-2-ol as a light brown oil.

Sources & evidence

ORD record
ord-2579d32dd66043068df199a34ac3804e
Source dataset
uspto-grants-2008_04
Patent number
US07365095B2

Linked notes

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