Tetrahydrofuran → 4'-Fluoro-4-methylbiphenyl-3-amine

Reaction equation

[Br:17][c:18]1[cH:19][cH:20][c:21]([CH3:25])[c:22]([NH2:23])[cH:24]1.[C:26](=[O:27])([O-:28])[O-:29].[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[CH3:1][C:2]1([CH3:3])[C:4]([CH3:5])([CH3:6])[O:7][B:8]([c:9]2[cH:10][cH:11][c:12]([F:15])[cH:13][cH:14]2)[O:16]1.[Cs+:30].[Cs+:31]>>[c:9]1(-[c:18]2[cH:19][cH:20][c:21]([CH3:25])[c:22]([NH2:23])[cH:24]2)[cH:10][cH:11][c:12]([F:15])[cH:13][cH:14]1

Participants

Reactant 5

HCID 8028Tetrahydrofuran

HCID 19660Carbonate Ion

HCID 104967Cesium cation2×

HCID 27348055-Bromo-o-toluidine

HCID 27605932-(4-Fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Product 1

HCID 463144304'-Fluoro-4-methylbiphenyl-3-amine

Sources & evidence

ORD record: ord-ebdce1d9de884eabb550c6ae74c8ae12
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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