Methyl 4-[4-(chloromethyl)-1,3-thiazol-2-yl]benzoate → 4-[4-(Chloromethyl)-1,3-thiazol-2-yl]benzoic acid
Reaction equation
[Cl:1][CH2:2][C:3]1[N:4]=[C:5]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14]C)=[O:13])=[CH:10][CH:9]=2)[S:6][CH:7]=1>Cl>[Cl:1][CH2:2][C:3]1[N:4]=[C:5]([C:8]2[CH:9]=[CH:10][C:11]([C:12]([OH:14])=[O:13])=[CH:16][CH:17]=2)[S:6][CH:7]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
An aqueous solution of HCl (6N, 200 mL) was added to methyl 4-[4-(chloromethyl)-1,3-thiazol-2-yl]benzoate (20.0 g, 0.075 mol) and refluxed overnight. The reaction mixture was allowed to cool to ambient temperatures and the solid was filtered and then dried in vacuo at 40° C. to give the title compound (15.0 g, 75%).
Workup
- temperaturerefluxed overnight
- temperatureto cool to ambient temperatures
- filtrationthe solid was filtered
- customdried in vacuo at 40° C.
Sources & evidence
- ORD record
- ord-838eed514c4e41c08fac337aa0623775
- Source dataset
- uspto-grants-2008_04
- Patent number
- US07365225B2
Reaction notes
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