Hydrochloric Acid → HCID 178492091, compound
Reaction equation
[NH2:1][C:2](=[S:16])[NH:3][N:4]([C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=1)[C:5](=O)[CH3:6].[OH-].[Na+].CO.Cl>O>[CH3:15][O:14][C:11]1[CH:12]=[CH:13][C:8]([N:4]2[C:5]([CH3:6])=[N:1][C:2]([SH:16])=[N:3]2)=[CH:9][CH:10]=1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 14.5 parts of acetic acid 2-(aminothioxomethyl)-1-(4-methoxyphenyl)hydrazide, 5 parts of sodium hydroxide and 80 parts of methanol is stirred and refluxed for 30 minutes. The reaction mixture is cooled and water is added. The whole is adjusted to pH 5 with a hydrochloric acid solution. The precipitated product is filtered off and dried, yielding 12.3 parts (91%) of 1-(4-methoxyphenyl)-5-methyl-1H-1,2,4-triazole-3-thiol.
Workup
- temperaturerefluxed for 30 minutes
- temperatureThe reaction mixture is cooled
- filtrationThe precipitated product is filtered off
- customdried
Sources & evidence
- ORD record
- ord-50cd2a6a539042589ed8d88d9cd8e301
- Source dataset
- uspto-grants-1980_10
- Patent number
- US04229581
Reaction notes
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