Allantoin → Hydrogen Peroxide

HRID 904269

Reaction equation

HRID 904269 reaction equation
[NH:1]1[C:11](=[O:12])[C:10]2[NH:9][C:7](=[O:8])[NH:6][C:5]=2[NH:4][C:2]1=[O:3].C1C(=O)NC(=O)N(C2OC(COP(OC3C(O)C(N4C(=O)NC(=O)C=C4)OC3CO)(O)=O)C(O)C2O)C=1.N.C1(NC(N)=O)NC(=O)NC1=O.[OH:62][OH:63]>>[C:10]12[C:11](=[O:12])[NH:1][C:2](=[O:3])[NH:4][C:5]=1[NH:6][C:7]([NH:9]2)=[O:8].[O:62]=[O:63].[OH:62][OH:63]

Participants

7

Reactant 4

HCID 204AllantoinHCID 784Hydrogen PeroxideHCID 1175Uric AcidHCID 14228836Urate Oxidase

Product 3

HCID 784Hydrogen PeroxideHCID 977OxygenHCID 1175Uric Acid

Procedure

Uric acid is oxidized enzymatically by uricase to allantoin and hydrogen peroxide at about pH 7. The stoichiometry of the enzyme reaction proper, regardless of buffer or pH, is given by equation (1), i.e., the transfer of an electron pair from the urate monoanion to oxygen, yielding an unstable acid intermediate (1-carboxy-2,4,6,8-tetraazabicycl [3,3,0]-octa-4-en-3,7-dione), and hydrogen peroxide.

Workup

  1. customThe stoichiometry of the enzyme reaction proper

Sources & evidence

ORD record
ord-6629332f5592460a80a0d8f3b57f726b
Source dataset
uspto-grants-1980_10
Patent number
US04230798

Linked notes

Loading…