Ethyl 3-bromo-2-oxocyclohexanecarboxylate → Ethyl 4,5,6,7-tetrahydro-2-methylbenzothiazole-5-carboxylate

HRID 905189

Reaction equation

HRID 905189 reaction equation

[C:1]([NH2:4])(=[S:3])[CH3:2].Br[CH:6]1[CH2:11][CH2:10][CH2:9][CH:8]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:7]1=O>>[CH3:2][C:1]1[S:3][C:11]2[CH2:10][CH2:9][CH:8]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:7][C:6]=2[N:4]=1

Participants

3

Reactant 2

HCID 121765Ethyl 3-bromo-2-oxocyclohexanecarboxylate

HCID 2723949Thioacetamide

Product 1

HCID 3018725Ethyl 4,5,6,7-tetrahydro-2-methylbenzothiazole-5-carboxylate

Procedure

The compound is prepared by action of thioacetamide on 2-bromo-5-ethoxycarbonyl cyclohexanone (II), as described in Example 1. B.P.0.4 =116°-120° C.

Workup

customB.P.0.4 =116°-120° C.

Sources & evidence

ORD record: ord-15e79ab0294346a4b11b26c328310fe4
Source dataset: uspto-grants-1983_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04423056

Linked notes

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