Acetic Anhydride → 2-Pyrrolidinone, 1-acetyl-

HRID 905607

Reaction equation

HRID 905607 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].[C:7](OC(=O)C)(=[O:9])[CH3:8]>>[C:7]([N:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6])(=[O:9])[CH3:8]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 120252-Pyrrolidone

Product 1

HCID 702662-Pyrrolidinone, 1-acetyl-Yield 96%

Procedure

A mixture of 112 g of 2-pyrrolidinone (9) and 249 mL of acetic anhydride was heated at reflux for 2 hours. The resultant mixture was allowed to cool to room temperature, was concentrated in vacuo, and was distilled (0.8 mm Hg, 68° C.) to provide 160 g of N-acetyl-2-pyrrolidinone (4) in 96% yield.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 2 hours
  3. concentrationwas concentrated in vacuo
  4. distillationwas distilled (0.8 mm Hg, 68° C.)

Sources & evidence

ORD record
ord-8d502b49ae6b464793197a75442691c1
Source dataset
uspto-grants-2011_09
Patent number
US08012969B2

Linked notes

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