Dichloromethane → 5-Methylazepan-4-One Hydrochloride
Reaction equation
C(OC([N:8]1[CH2:14][CH2:13][C:12](=[O:15])[CH:11]([CH3:16])[CH2:10][CH2:9]1)=O)(C)(C)C.C(Cl)[Cl:18]>C(O)(C(F)(F)F)=O>[ClH:18].[CH3:16][CH:11]1[CH2:10][CH2:9][NH:8][CH2:14][CH2:13][C:12]1=[O:15]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 4-methyl-5-oxo-azepane-1-carboxylic acid tert-butyl ester (700 mg, 3.083 mmol) was dissolved in 10% TFA in DCM (30 mL) and stirred at RT for 6 hours before being evaporated to give 0.74 g of 5-methyl-azepan-4-one hydrochloride.
Workup
- custombefore being evaporated
Sources & evidence
- ORD record
- ord-83bde626cdc44d4082903f2e2350d34f
- Source dataset
- uspto-grants-2011_09
- Patent number
- US08012974B2
Reaction notes
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