Dimethylformamide → 1,1-Dimethylethyl (1-{2-hydroxy-3-[7-(methyloxy)-2-oxo-3,4-dihydro-1,8-naphthyridin-1(2H)-yl]propyl}-4-piperidinyl)carbamate

HRID 90602

Reaction equation

HRID 90602 reaction equation
[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:11]([n:12]1)[N:10]([CH2:13][CH:14]1[O:15][CH2:16]1)[C:9](=[O:17])[CH2:8][CH2:7]2.[N+:18]([c:19]1[cH:20][c:21]([S:22]([O:23][CH2:24][CH:25]2[CH2:26][O:27]2)(=[O:28])=[O:29])[cH:30][cH:31][cH:32]1)([O-:33])=[O:34].[NH:35]1[CH2:36][CH2:37][CH:38]([NH:41][C:42]([O:43][C:44]([CH3:45])([CH3:46])[CH3:47])=[O:48])[CH2:39][CH2:40]1.[O:49]=[CH:50][N:51]([CH3:52])[CH3:53]>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:11]([n:12]1)[N:10]([CH2:13][CH:14]([OH:15])[CH2:16][N:35]1[CH2:36][CH2:37][CH:38]([NH:41][C:42]([O:43][C:44]([CH3:45])([CH3:46])[CH3:47])=[O:48])[CH2:39][CH2:40]1)[C:9](=[O:17])[CH2:8][CH2:7]2

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 286836(Oxiran-2-yl)methyl 3-nitrobenzene-1-sulfonateHCID 7238334-(N-Boc-amino)piperidineHCID 866420917-(Methyloxy)-1-(2-oxiranylmethyl)-3,4-dihydro-1,8-naphthyridin-2(1H)-one

Product 1

HCID 690465561,1-Dimethylethyl (1-{2-hydroxy-3-[7-(methyloxy)-2-oxo-3,4-dihydro-1,8-naphthyridin-1(2H)-yl]propyl}-4-piperidinyl)carbamate

Sources & evidence

ORD record
ord-7940d133b9aa4bd88f367289ad5165e9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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