Water → N'-(4-Chlorophenyl)acetohydrazide

HRID 906479

Reaction equation

HRID 906479 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][NH2:10])=[CH:5][CH:4]=1.C(N([CH2:16][CH3:17])CC)C.[OH2:18]>>[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][NH:10][C:16](=[O:18])[CH3:17])=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 962WaterHCID 8471TriethylamineHCID 71600Hydrazine, (4-chlorophenyl)-, hydrochloride (1:1)

Product 1

HCID 245209N'-(4-Chlorophenyl)acetohydrazide

Conditions

Temperature
0 °C

Procedure

12.5 g of 4-chlorophenylhydrazine hydrochloride are dissolved in 100 ml of water and then triethylamine is added until the salt has been neutralized. Extraction is carried out with AcOEt and then the extract is evaporated to dryness. The base is dissolved in 100 ml of ether, the solution is cooled to 0° C. and then 15 ml of acetic anhydride are added dropwise. The mixture is stirred at 0° C. for 15 minutes. The white precipitate formed is filtered off and is then washed with ether to produce 12.8 g of the expected compound in the form of a white powder.

Workup

  1. extractionExtraction
  2. customthe extract is evaporated to dryness
  3. dissolutionThe base is dissolved in 100 ml of ether
  4. addition15 ml of acetic anhydride are added dropwise
  5. customThe white precipitate formed
  6. filtrationis filtered off
  7. washis then washed with ether

Sources & evidence

ORD record
ord-f8e7896bab57401bbf915fd5deba8d5f
Source dataset
uspto-grants-2011_09
Patent number
US08012991B2

Linked notes

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