Dimethylamine → Dimethyl-[(2-methyl-1H-indol-3-yl)-(4-trifluoromethyl-phenyl)-methyl]-amine
Reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2.[Cl-].[F:12][C:13]([F:25])([F:24])[C:14]1[CH:23]=[CH:22][C:17]([CH:18]=[N+:19]([CH3:21])[CH3:20])=[CH:16][CH:15]=1.FC(F)(F)C1C=CC(C=O)=CC=1.CNC>>[CH3:20][N:19]([CH3:21])[CH:18]([C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[NH:3][C:2]=1[CH3:1])[C:17]1[CH:16]=[CH:15][C:14]([C:13]([F:12])([F:24])[F:25])=[CH:23][CH:22]=1Participants
5
Procedure
The preparation was carried out in accordance with general synthesis instructions 4 from 2-methyl-1H-indole and (4-trifluoromethyl-benzylidene)-dimethylammonium chloride, which had been prepared in accordance with example 44 from 4-trifluoromethyl-benzaldehyde and dimethylamine.