HomeMCPWorkbenchSkills
HomeWorkbenchNotificationsMe
llms.txt · MCP GuidePrivacy Policy · Terms of Service · Supportv1.8.0
  1. Home
  2. /Reaction

Hydrochloric Acid → 2-(4-Dimethylamino-4-phenylcyclohexyl)-N-[6-(1H-indol-3-yl)hexyl]acetamide hydrochloride

HRID 908978
Notes
Print preview

Reaction equation

HRID 908978 reaction equation
[CH3:1][N:2]([CH3:34])[C:3]1([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH2:8][CH2:7][CH:6]([CH2:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[NH:21][CH:20]=2)=[O:11])[CH2:5][CH2:4]1.[ClH:35]>CC(CC)=O.C(O)C>[ClH:35].[CH3:34][N:2]([CH3:1])[C:3]1([C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH2:8][CH2:7][CH:6]([CH2:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[NH:21][CH:20]=2)=[O:11])[CH2:5][CH2:4]1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 116129622-(4-Dimethylamino-4-phenylcyclohexyl)-N-[6-(1H-indol-3-yl)hexyl]acetamide

Product 1

HCID 116129612-(4-Dimethylamino-4-phenylcyclohexyl)-N-[6-(1H-indol-3-yl)hexyl]acetamide hydrochlorideYield 62%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 6569
Methyl Ethyl Ketone
Solvent

Procedure

2-(4-Dimethylamino-4-phenylcyclohexyl)-N-[6-(1H-indol-3-yl)hexyl]acetamide (516 mg, 1.12 mmol) was dissolved in a mixture of ethyl methyl ketone (25 ml) and ethanol (5 ml), and 5 M isopropanolic hydrochloric acid (0.44 ml, 2.2 mmol) was added. After 3 h the reaction mixture was concentrated, ether (15 ml) was added and the mixture was concentrated again. The residue was digested with ether (30 ml). After filtration, the product was obtained as a beige-coloured solid in a yield of 62% (342 mg).

Workup

  1. additionwas added
  2. concentrationAfter 3 h the reaction mixture was concentrated
  3. additionether (15 ml) was added
  4. concentrationthe mixture was concentrated again
  5. filtrationAfter filtration
  6. customthe product was obtained as a beige-coloured solid in a yield of 62% (342 mg)

Sources & evidence

ORD record
ord-6c8b986d440341758fdbcabc423f99f3
Source dataset
uspto-grants-2011_09
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08017630B2

Reaction notes

Loading…

On this pageParticipantsProcedureWorkupSources & evidenceReaction notes