Trimethylsilyldiazomethane → HCID 57419860, compound

HRID 909915Notes

Reaction equation

HRID 909915 reaction equation
[N+](=[CH:3][Si](C)(C)C)=[N-].[Br:8][C:9]1[CH:10]=[C:11]([CH2:16][C:17]([OH:19])=[O:18])[CH:12]=[CH:13][C:14]=1[F:15]>C(OCC)C.ClCCl.CO>[Br:8][C:9]1[CH:10]=[C:11]([CH2:16][C:17]([O:19][CH3:3])=[O:18])[CH:12]=[CH:13][C:14]=1[F:15]

Participants

6

Reactant 2

HCID 167693TrimethylsilyldiazomethaneHCID 34163393-Bromo-4-fluorophenylacetic Acid

Product 1

HCID 57419860HCID 57419860, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

A solution of (diazomethyl)trimethylsilane (12.87 mL) in diethyl ether was added to an ice-batch cooled solution of 2-(3-bromo-4-fluorophenyl)acetic acid (3 g) in dichloromethane (20 mL) and methanol (5 mL). The mixture was stirred for 10 min. and concentrated in vacuo to give methyl 2-(3-bromo-4-fluorophenyl)acetate (3.20 g) that was

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-80960c89fff84353833007ac484a4262
Source dataset
uspto-grants-2011_09
Patent number
US08017602B2

Reaction notes

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