Ammonia → N-p-Bromophenylthiourea

HRID 910227

Reaction equation

HRID 910227 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]=[C:9]=[S:10])=[CH:4][CH:3]=1.[NH3:11]>O1CCCC1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH2:11])=[S:10])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 161334-Bromophenyl isothiocyanate

Product 1

HCID 2735620N-p-Bromophenylthiourea

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

4-Bromophenylisothiocyanate (21.4 g) was dissolved in tetrahydrofuran (50 mL), and concentrated aqueous ammonia (28%) (13.7 mL) was added dropwise to the solution, followed by stirring at room temperature for 10 minutes. The solvent was concentrated under reduced pressure, and the crystals were recovered through filtration by use of water, followed by recrystallization from ethanol, to thereby yield the title compound (16.4 g).

Workup

  1. concentrationThe solvent was concentrated under reduced pressure
  2. filtrationthe crystals were recovered through filtration by use of water
  3. customfollowed by recrystallization from ethanol

Sources & evidence

ORD record
ord-21dc0986b22b4059a3b8ea7a202da54c
Source dataset
uspto-grants-2011_09
Patent number
US08022075B2

Linked notes

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