2-(Tri-n-butylstannyl)thiophene → 1-Methyl-4-(5-thiophen-2-yl-pyridin-3-yl)-piperazine

Participants

Role	Name	HCID	Charge
Reactant	2-(Tri-n-butylstannyl)thiophene	HCID 2779373	—
Reactant	1-(5-Bromopyridin-3-yl)-4-methylpiperazine	HCID 53485314	—
Catalyst	HCID 178418397	HCID 178418397	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	1-Methyl-4-(5-thiophen-2-yl-pyridin-3-yl)-piperazine	HCID 22632288	—

Reaction Conditions

Temperature	100 °C

Reaction Steps

To a vial was added 1-(5-bromo-pyridin-3-yl)-4-methyl-piperazine (47 mg, 0.13 mmol), Pd(PPh3)4 (34 mg), 2-thienyltributylstannane (67 mg, 0.15 mmol) and dioxane (1 mL). The resulting mixture was heated at 100° C. for 24 hrs. The resulting mixture was extracted with EtOAc. The organic layer was dried and concentrated, and the residue was purified by preparative TLC (hexanes/EtOAc) to yield the title compound as a solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08022209B2
Source dataset	uspto-grants-2011_09
ORD ID	ord-f590971f92df40c184810059889b07ef
Source note	uspto-grants-2011_09