N,N-Dimethylethylenediamine → HCID 86634755, compound
Reaction equation
[ClH:1].[CH3:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=O)=[CH:5][C:4]=1[O:12][C:13]1[CH:18]=[CH:17][N:16]=[C:15]([NH:19][C:20]2[S:21][CH:22]=[C:23]([CH3:25])[N:24]=2)[CH:14]=1.[CH3:26][N:27]([CH3:31])[CH2:28][CH2:29][NH2:30]>>[ClH:1].[ClH:1].[CH3:26][N:27]([CH3:31])[CH2:28][CH2:29][NH:30][C:7](=[O:9])[C:6]1[CH:10]=[CH:11][C:3]([CH3:2])=[C:4]([O:12][C:13]2[CH:18]=[CH:17][N:16]=[C:15]([NH:19][C:20]3[S:21][CH:22]=[C:23]([CH3:25])[N:24]=3)[CH:14]=2)[CH:5]=1Participants
3
Procedure
The title compound was prepared according to the method of Example 107 from 4-methyl-3-(2-(4-methylthiazol-2-ylamino)pyridin-4-yloxy)benzoic acid hydrochloride (Example 108) and N,N-dimethylethylenediamine. Yield: 0.065 g, 25%. 1H NMR (CDCl3), 8.84 (bs, 1H), 8.16 (d, 1H), 7.90 (d, 1H), 7.86 (bs, 1H), 7.37 (d, 1H), 6.80 (bs, 1H), 6.71 (dd, 1H), 6.38 (s, 1H), 3.89 (m, 2H), 3.35 (m, 2H), 2.91 (s, 6H), 2.37 (s, 3H), 2.22 (s, 3H).
Sources & evidence
- ORD record
- ord-55ee145dd2f84b838e91ff4e608d169d
- Source dataset
- uspto-grants-2011_09