Ammonia → HCID 178514164, compound
Reaction equation
[N:1]1[NH:2][C:3](NC)=[CH:4][CH:5]=1.[C:8]([N:16]=[C:17]=[S:18])(=O)C1C=CC=CC=1.[NH3:19]>CO>[NH:1]1[CH:5]=[CH:4][C:3]([CH2:8][NH:16][C:17]([NH2:19])=[S:18])=[N:2]1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
The title compound was prepared in accordance with the general method described in Example 12(a) by using 2H-pyrazol-3-yl-methylamine (1.20 g, 12.4 mmol), benzoyl isothiocyanate (1.8 mL, 13.6 mmol) and ammonia in methanol (7N, 60 mL) with the exception that the crude product isolated by filtration (1.39 g, 72% yield) was used in the next step without further purification. MS (ESI) m/z 157 (M+1)
Workup
- customisolated by filtration (1.39 g, 72% yield)
- customwas used in the next step without further purification
Sources & evidence
- ORD record
- ord-4e26e5919d2b42cf8a9cf0d7caae231b
- Source dataset
- uspto-grants-2011_09
- Patent number
- US08026244B2
Reaction notes
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