Piperazine → 2-(1-piperazinyl)-8-Quinolinol

Reaction equation

Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[C:5]([OH:12])[CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>>[OH:12][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:4]=1[N:3]=[C:2]([N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)[CH:11]=[CH:10]2

Participants

Reactant 2

HCID 4837Piperazine

HCID 2748782-Chloroquinolin-8-ol

Product 1

HCID 674023752-(1-piperazinyl)-8-Quinolinol

Procedure

The quinoline from step (a) above (0.18 g, 1 mmol) and piperazine (0.172 g, 2 mmol, Aldrich) reacted under the conditions of Example 3a to give the title compound as a white solid.

Sources & evidence

ORD record: ord-fb41925256fb4855bed85e1dcdc002a5
Source dataset: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08026241B2

Reaction notes

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