Trifluoroacetic acid → HCID 59758809, compound
Reaction equation
[CH3:1][C:2]([S:7][C:8]1[S:9][CH:10]=[C:11]([CH2:13][C:14]([N:16]([CH3:23])[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=O)[N:12]=1)([CH3:6])[C:3]([OH:5])=[O:4].FC(F)(F)C(O)=O>>[CH3:6][C:2]([S:7][C:8]1[S:9][CH:10]=[C:11]([CH2:13][CH2:14][N:16]([CH3:23])[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[N:12]=1)([CH3:1])[C:3]([OH:5])=[O:4]Participants
3
Procedure
To the resin obtained using 2-methyl-2-[(4-{2-[methyl(phenyl)amino]-2-oxoethyl}-1,3-thiazol-2-yl)thio]propionic acid resin obtained in Example 487-1 as a starting material and by an operation similar to that of Example 461-6 was added trifluoroacetic acid (2.0 mL), and the mixture was left standing as it was for 2 hr. Then the resin was removed by filtration from the reaction mixture, and the filtrate was concentrated by blowing a nitrogen gas, vacuum dried, and purified by preparative HPLC to give the title compound (30 mg) as a pale-brown oil.
Workup
- customTo the resin obtained
- waitthe mixture was left
- customThen the resin was removed by filtration from the reaction mixture