N-p-Bromophenylthiourea → N-[7-(4-Bromoanilino)-4,5-dihydro[1,3]thiazolo[4',5': 3,4]benzo[d][1,3]thiazol-2-yl]-N'-ethylurea

HRID 9153

Reaction equation

Br[CH:2]1[CH2:16][CH2:15][C:5]2[N:6]=[C:7]([NH:9][C:10]([NH:12][CH2:13][CH3:14])=[O:11])[S:8][C:4]=2[C:3]1=O.[Br:18][C:19]1[CH:24]=[CH:23][C:22]([NH:25][C:26]([NH2:28])=[S:27])=[CH:21][CH:20]=1>C1COCC1>[Br:18][C:19]1[CH:24]=[CH:23][C:22]([NH:25][C:26]2[S:27][C:2]3[CH2:16][CH2:15][C:5]4[N:6]=[C:7]([NH:9][C:10]([NH:12][CH2:13][CH3:14])=[O:11])[S:8][C:4]=4[C:3]=3[N:28]=2)=[CH:21][CH:20]=1

Participants

Conditions

Temperature: 65 °C

Procedure

A suspension of N-(6-bromo-7-oxo-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)-N′-ethylurea (50 mg, 0.16 mmol) and 4-bromo-phenyl-thiourea (36 mg, 0.16 mmol) in THF (1.0 mL) was heated to about 65° C. for about 1.5 hrs. The reaction mixture was pumped down and used in the next step without further purification.

Workup

customused in the next step without further purification

Sources & evidence

ORD record: ord-ea8233a5c256454ba3ea6ba2c519a36d
Source dataset: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07091227B2

Linked notes

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