Tetrabutylammonium Fluoride → [2,4-dimethyl-5-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-methanol
Reaction equation
C([SiH2][O:6][C:7](C)(C)[C:8]1[N:12]([CH3:13])[N:11]=[C:10]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)[C:9]=1[CH3:24])(C)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>C1COCC1>[CH3:13][N:12]1[C:8]([CH2:7][OH:6])=[C:9]([CH3:24])[C:10]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:21])([F:23])[F:22])=[CH:16][CH:15]=2)=[N:11]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
In analogy to the procedure described for example 2 e], 5-(tert-butyl-dimethyl-silanyloxymethyl)-1,4-dimethyl-3-(4-trifluoromethyl-phenyl)-1H-pyrazole was treated with tetrabutylammonium fluoride in THF to yield [2,4-dimethyl-5-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-methanol as yellow oil.