Sodium Hydroxide → 2-(2-Diazoethoxy)oxane
Reaction equation
[N:1]([N:3]([CH2:7][CH2:8][O:9][CH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][O:11]1)C(N)=O)=O.[OH-].[Na+]>CCOCC.CCCCC>[O:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH:10]1[O:9][CH2:8][CH:7]=[N+:3]=[N-:1]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
A solution of 41.8 g of N-nitroso-N-[2-(tetrahydropyran-2-yloxy)ethyl]urea in 200 ml of ether and 100 ml of pentane is added to 450 ml of 1N sodium hydroxide solution at 1°-4°C over a 25 minute period. The solution is stirred for an additional 30 minutes and the layers are separated. The organic layer is dried over sodium hydroxide pellets at 20°C for 5 minutes, and then filtered.
Workup
- customthe layers are separated
- dry with materialThe organic layer is dried over sodium hydroxide pellets at 20°C for 5 minutes
- filtrationfiltered
Sources & evidence
- ORD record
- ord-c6d1dfda6f174052997187d1696d498c
- Source dataset
- uspto-grants-1976_07
- Patent number
- US03971773
Reaction notes
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