Potassium Cation → 4-(1,2,3,4-Tetrahydro-isoquinolin-6-yloxy)-benzamide

Reaction equation

[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][c:10]2[cH:11][cH:12][c:13]([O:18][c:19]3[cH:20][cH:21][c:22]([C:25]([NH2:26])=[O:27])[cH:23][cH:24]3)[cH:14][c:15]2[CH2:16][CH2:17]1)([CH3:5])([CH3:6])[CH3:7].[Cl:41][CH2:42][Cl:43].[F:28][C:29]([F:30])([F:31])[C:32]([OH:33])=[O:34].[K+:35].[K+:36].[O-:37][C:38]([O-:39])=[O:40]>>[NH:8]1[CH2:9][c:10]2[cH:11][cH:12][c:13]([O:18][c:19]3[cH:20][cH:21][c:22]([C:25]([NH2:26])=[O:27])[cH:23][cH:24]3)[cH:14][c:15]2[CH2:16][CH2:17]1

Participants

Reactant 5

HCID 813Potassium Cation2×

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 19660Carbonate Ion

HCID 597299826-(4-carbamoyl-phenoxy)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Product 1

HCID 597301424-(1,2,3,4-Tetrahydro-isoquinolin-6-yloxy)-benzamide

Sources & evidence

ORD record: ord-9282dc35b7bf4e17a4a4b5b34d3bc922
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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