2-Methoxyethylamine → 2-Amino-5-[4-(2-methoxy-ethylcarbamoyl)-phenyl]-N-pyridin-4-yl-nicotinamide
Reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:16]=[CH:15][C:11]([C:12](O)=[O:13])=[CH:10][CH:9]=2)=[CH:4][C:3]=1[C:17](=[O:25])[NH:18][C:19]1[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=1.[CH3:26][O:27][CH2:28][CH2:29][NH2:30]>>[NH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:16]=[CH:15][C:11]([C:12](=[O:13])[NH:30][CH2:29][CH2:28][O:27][CH3:26])=[CH:10][CH:9]=2)=[CH:4][C:3]=1[C:17]([NH:18][C:19]1[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=1)=[O:25]Participants
3
Procedure
Reaction of 4-[6-amino-5-(pyridin-4-ylcarbamoyl)-pyridin-3-yl]-benzoic acid with 2-methoxy-ethylamine gives “A92”; method 1: HPLC/MS: 1.25 min, [M+H]=392;
Workup
- customgives “A92”
- custom1.25 min, [M+H]=392
Sources & evidence
- ORD record