2-Bromoethanol → HCID 19622756, compound

Reaction equation

[OH:1][C:2]1C(OCCC)=CC(C=O)=C[C:3]=1[N+]([O-])=O.[OH:17][C:18]1[CH:19]=[C:20]([CH:23]=[CH:24][C:25]=1[O:26][CH3:27])[CH:21]=[O:22].BrCCO>>[OH:1][CH2:2][CH2:3][O:17][C:18]1[CH:19]=[C:20]([CH:23]=[CH:24][C:25]=1[O:26][CH3:27])[CH:21]=[O:22]

Participants

Reactant 3

HCID 108982-Bromoethanol

HCID 12127Isovanillin

HCID 573549704-Hydroxy-3-nitro-5-propoxybenzaldehyde

Product 1

HCID 19622756HCID 19622756, compound

Procedure

Followed procedure described in Intermediate 65, step 2 starting from 3-hydroxy-4-methoxybenzaldehyde and 2-bromoethanol, using crude material for next step.

Sources & evidence

ORD record: ord-e4dd2c4eb8e343608ccc6a87cd2ab0dd
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09283229B2

Reaction notes

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