Ethyl formate → N-(4-dimethylaminobutyl)formamide
Reaction equation
[CH3:1][N:2]([CH3:8])[CH2:3][CH2:4][CH2:5][CH2:6][NH2:7].[CH:9](OCC)=[O:10]>>[CH3:1][N:2]([CH3:8])[CH2:3][CH2:4][CH2:5][CH2:6][NH:7][CH:9]=[O:10]Participants
3
Procedure
A solution of 4-dimethylaminobutylamine (3.0 g) in ethyl formate (30 mL) was stirred and heated at reflux under an atmosphere of nitrogen for 3 hours. After cooling, the mixture was evaporated to dryness and the residue was purified by chromatography on silica, eluting with a mixture of methanol and DCM (20%) to give N-(4-dimethylaminobutyl)formamide (2.7 g) as a pale yellow oil.
Workup
- temperatureheated
- temperatureat reflux under an atmosphere of nitrogen for 3 hours
- temperatureAfter cooling
- customthe mixture was evaporated to dryness
- customthe residue was purified by chromatography on silica
- washeluting with a mixture of methanol and DCM (20%)
Sources & evidence
- ORD record
- ord-80c57ad9e6fd47408c1b2686fd0f3111
- Source dataset
- uspto-grants-2016_03
- Patent number
- US09290472B2
Reaction notes
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