Dimethylformamide dimethyl acetal → 4-(Dimethylamino)-1,1-dimethoxybut-3-en-2-one

HRID 931109Notes

Reaction equation

HRID 931109 reaction equation
CO[CH:3](OC)[N:4]([CH3:6])[CH3:5].[CH3:9][O:10][CH:11]([O:15][CH3:16])[C:12](=[O:14])[CH3:13]>>[CH3:3][N:4]([CH3:6])[CH:5]=[CH:13][C:12](=[O:14])[CH:11]([O:15][CH3:16])[O:10][CH3:9]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 80650Pyruvic aldehyde dimethyl acetal

Product 1

HCID 27821454-(Dimethylamino)-1,1-dimethoxybut-3-en-2-one

Conditions

Temperature
80 °C

Procedure

A mixture of 1,1-dimethoxy-N,N-dimethylmethanamine (5.0 g, 41.96 mmol) and 1,1-dimethoxypropan-2-one (5.0 g, 41.96 mmol) was heated to 80° C. for 16 h. The solvent was removed under reduced pressure to afford 4-(dimethylamino)-1,1-dimethoxybut-3-en-2-one as a black colored liquid. The material was used without further purification.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-d69cd11f1fbc4e098327bd191764cd2d
Source dataset
uspto-grants-2016_03
Patent number
US09296745B2

Reaction notes

Loading…