Hydrochloric Acid → methyl 2-morpholino-4-oxo-8-(pyrrolidin-2-yl)-4H-chromene-6-carboxylate

Reaction equation

[CH3:2][O:3][C:4](=[O:5])[c:6]1[cH:7][c:8]2[c:9](=[O:34])[cH:10][c:11]([N:28]3[CH2:29][CH2:30][O:31][CH2:32][CH2:33]3)[o:12][c:13]2[c:14]([CH:16]2[N:17]([C:21]([O:22][C:23]([CH3:24])([CH3:25])[CH3:26])=[O:27])[CH2:18][CH2:19][CH2:20]2)[cH:15]1.[Cl:35][CH2:36][Cl:37].[ClH:1]>>[CH3:2][O:3][C:4](=[O:5])[c:6]1[cH:7][c:8]2[c:9](=[O:34])[cH:10][c:11]([N:28]3[CH2:29][CH2:30][O:31][CH2:32][CH2:33]3)[o:12][c:13]2[c:14]([CH:16]2[NH:17][CH2:18][CH2:19][CH2:20]2)[cH:15]1

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 6344Dichloromethane

HCID 86672404tert-butyl 2-(6-(methoxycarbonyl)-2-morpholino-4-oxo-4H-chromen-8-yl)pyrrolidine-1-carboxylate

Product 1

HCID 86672405methyl 2-morpholino-4-oxo-8-(pyrrolidin-2-yl)-4H-chromene-6-carboxylate

Sources & evidence

ORD record: ord-9a06d926d83f45aab07fe7cf8fffa04d
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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