Tributylphosphine → (4-{3-[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-propoxy}-indol-1-yl)-acetic acid tert-butyl ester

HRID 932932

Reaction equation

HRID 932932 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([CH2:7][n:8]1[cH:9][cH:10][c:11]2[c:12]([OH:17])[cH:13][cH:14][cH:15][c:16]12)=[O:18].[CH2:39]([P:40]([CH2:41][CH2:42][CH2:43][CH3:44])[CH2:45][CH2:46][CH2:47][CH3:48])[CH2:49][CH2:50][CH3:51].[CH3:19][c:20]1[n:21][c:22](-[c:29]2[cH:30][cH:31][c:32]([C:35]([F:36])([F:37])[F:38])[cH:33][cH:34]2)[s:23][c:24]1[CH2:25][CH2:26][CH2:27][OH:28]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([CH2:7][n:8]1[cH:9][cH:10][c:11]2[c:12]([O:17][CH2:27][CH2:26][CH2:25][c:24]3[c:20]([CH3:19])[n:21][c:22](-[c:29]4[cH:30][cH:31][c:32]([C:35]([F:36])([F:37])[F:38])[cH:33][cH:34]4)[s:23]3)[cH:13][cH:14][cH:15][c:16]12)=[O:18]

Participants

4

Reactant 3

HCID 13831TributylphosphineHCID 236144873-[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-propan-1-olHCID 69279689tert-Butyl (4-hydroxy-1H-indol-1-yl)acetate

Product 1

HCID 69280204(4-{3-[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-propoxy}-indol-1-yl)-acetic acid tert-butyl ester

Sources & evidence

ORD record
ord-aca61487b4b24c85af768cb9220cdd1f
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Linked notes

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