Dichloromethane → 2-Bromo-1-{(3RS,4SR)-3-(3,4-dichloro-phenyl)-4-[(RS)-1-(4-trifluoromethyl-phenoxy)-ethyl]-pyrrolidin-1-yl}-ethanone

HRID 93317

Reaction equation

HRID 93317 reaction equation
[Br:34][CH2:35][C:36](=[O:37])[Cl:38].[CH3:27][CH2:28][N:29]([CH2:30][CH3:31])[CH2:32][CH3:33].[Cl:1][c:2]1[cH:3][c:4]([CH:9]2[CH2:10][NH:11][CH2:12][CH:13]2[CH:14]([CH3:15])[O:16][c:17]2[cH:18][cH:19][c:20]([C:23]([F:24])([F:25])[F:26])[cH:21][cH:22]2)[cH:5][cH:6][c:7]1[Cl:8].[Cl:39][CH2:40][Cl:41]>>[Cl:1][c:2]1[cH:3][c:4]([CH:9]2[CH2:10][N:11]([C:36]([CH2:35][Br:34])=[O:37])[CH2:12][CH:13]2[CH:14]([CH3:15])[O:16][c:17]2[cH:18][cH:19][c:20]([C:23]([F:24])([F:25])[F:26])[cH:21][cH:22]2)[cH:5][cH:6][c:7]1[Cl:8]

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 89602Bromoacetyl chlorideHCID 67131736(3RS,4SR)-3-(3,4-Dichloro-phenyl)-4-[(RS)-1-(4-trifluoromethyl-phenoxy)-ethyl]-pyrrolidine

Product 1

HCID 766116022-Bromo-1-{(3RS,4SR)-3-(3,4-dichloro-phenyl)-4-[(RS)-1-(4-trifluoromethyl-phenoxy)-ethyl]-pyrrolidin-1-yl}-ethanone

Sources & evidence

ORD record
ord-705e92f183c646fdb6a2746ede73d16d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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