Chloroform → N-(2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)-2,2,2-trifluoro-N-(piperidin-3-ylmethyl)acetamide

Reaction equation

[CH:33]([Cl:34])([Cl:35])[Cl:36].[O:1]1[CH2:2][CH2:3][O:4][c:5]2[cH:6][n:7][c:8]([CH2:11][N:12]([C:13]([C:14]([F:15])([F:16])[F:17])=[O:18])[CH2:19][CH:20]3[CH2:21][N:22]([C:26]([O:27][C:28]([CH3:29])([CH3:30])[CH3:31])=[O:32])[CH2:23][CH2:24][CH2:25]3)[cH:9][c:10]21.[OH:37][C:38]([C:39]([F:40])([F:41])[F:42])=[O:43]>>[O:1]1[CH2:2][CH2:3][O:4][c:5]2[cH:6][n:7][c:8]([CH2:11][N:12]([C:13]([C:14]([F:15])([F:16])[F:17])=[O:18])[CH2:19][CH:20]3[CH2:21][NH:22][CH2:23][CH2:24][CH2:25]3)[cH:9][c:10]21