Water → Ethyl 2-chloro-4-phenyl-1,3-thiazole-5-carboxylate

Reaction equation

[O:1]=[c:2]1[s:3][c:4]([C:13](=[O:14])[O:15][CH2:16][CH3:17])[c:5](-[c:7]2[cH:8][cH:9][cH:10][cH:11][cH:12]2)[nH:6]1.[OH2:23].[P:18]([Cl:19])([Cl:20])([Cl:21])=[O:22]>>[c:2]1([Cl:20])[s:3][c:4]([C:13](=[O:14])[O:15][CH2:16][CH3:17])[c:5](-[c:7]2[cH:8][cH:9][cH:10][cH:11][cH:12]2)[n:6]1

Participants

Reactant 3

HCID 962Water

HCID 24813Phosphorus oxychloride

HCID 13041815Ethyl 2,3-dihydro-2-oxo-4-phenyl-5-thiazolecarboxylate

Product 1

HCID 13041816Ethyl 2-chloro-4-phenyl-1,3-thiazole-5-carboxylate

Sources & evidence

ORD record: ord-f458f17d66934c81983266d1a790122e
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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