Phosphorus oxychloride → (7-Bromo-1-chloro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine
Reaction equation
[Br:1][c:2]1[c:3]([O:20][CH3:21])[cH:4][c:5]2[cH:6][c:7]([NH:13][c:14]3[n:15][nH:16][c:17]([CH3:19])[cH:18]3)[n:8][c:9]([OH:12])[c:10]2[cH:11]1.[P:22]([Cl:23])([Cl:24])([Cl:25])=[O:26]>>[Br:1][c:2]1[c:3]([O:20][CH3:21])[cH:4][c:5]2[cH:6][c:7]([NH:13][c:14]3[n:15][nH:16][c:17]([CH3:19])[cH:18]3)[n:8][c:9]([Cl:24])[c:10]2[cH:11]1Participants
3
Sources & evidence
- ORD record
- ord-e6751c6727784279915bd04708f15607
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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