Acetone → 4-(6-Bromopyridin-2-yl)-2-methylbut-3-yn-2-ol

HRID 945022

Reaction equation

HRID 945022 reaction equation
[Br:6][c:7]1[n:8][c:9]([C:13]#[CH:14])[cH:10][cH:11][cH:12]1.[CH2:1]([Li:2])[CH2:3][CH2:4][CH3:5].[CH3:15][C:16]([CH3:17])=[O:18].[O:19]1[CH2:20][CH2:21][CH2:22][CH2:23]1>>[Br:6][c:7]1[n:8][c:9]([C:13]#[C:14][C:16]([CH3:15])([CH3:17])[OH:18])[cH:10][cH:11][cH:12]1

Participants

5

Reactant 4

HCID 180AcetoneHCID 8028TetrahydrofuranHCID 129705322-Bromo-6-ethynylpyridineHCID 178418339Butyllithium

Product 1

HCID 595258794-(6-Bromopyridin-2-yl)-2-methylbut-3-yn-2-ol

Sources & evidence

ORD record
ord-8419c1af398543a9af9801631525d052
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Linked notes

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